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phenobarbital will minimize the extent or outcome of alfentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.phenobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with potent CYP3A4 inducers; these prescription d